The design inference uncovers intelligent causes by isolating the key trademark of intelligent causes: specified events of small probability. Just about anything that happens is highly improbable, but when a highly improbable event is also specified (i.e., conforms to an independently given pattern) undirected natural causes lose their explanatory power. Design inferences can be found in a range of scientific pursuits from forensic science to research into the origins of life to the search for extraterrestrial intelligence.